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其實以生酮飲食治療癲癇發作不是什麼新點子，聖經上就有斷食控制癲癇發作的記載。一但進食又發作了，可是長期挨餓是不可能的，第一個有關生酮飲食的科學性報導，出自於1910年的法國；而美國最早的報告是由梅約診所的Wilder醫師於1921年所提出。由於生酮飲食準備上較為繁瑣，而逐漸為二十世紀後半出現的抗癲癇藥物取代；尤其是屬於脂肪酸之一的藥物帝拔癲的出現，使許多人誤以為此藥和生酮飲食有相同的作用機轉。加上飲食治療無法作雙盲試驗，被許多專家以不夠科學為由予以拋棄。直到九O年代，透過實際獲益的癲癇兒Charlie之家長的成立基金會大力鼓吹，初期不斷在美國三大電視網登廣告，後來更斥資拍攝電影“First Do No Harm”（台灣譯名：不要傷害我的小孩），加上約翰霍普金斯醫院Freeman醫師等人的努力推動，生酮飲食在癲癇治療上的角色，才得以在二十世紀結束之前重新受到肯定與重視。
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